The growth of the brain of human embryo is changing through a long time in the body of mother. So it is very difficult to observe and to understand that process. Therefore, the embryologists found the realistic human organ models and animations necessary for their studies. But to create the realistic human embryo brain models and to do the animations it requires an appropriate methodology. The aim of this paper is to present a developing methodology based on the functional representation and the convolution of the surfaces [4,5,6]. We employed this to create a growth simulation of the human embryo brain. The idea of this technique is the following. As a first step the 2D central skeleton is created from an artistic drawing and then the 3D skeleton is modeled by adding the thickness. As the next step, the skeletons representing key-frame models are used to create an animation. At the end the gap between the key-frame models is filled by the suitable interpolation techniques and finally the animation is composed.